High-Grade Serous Ovarian Tumor Cells Modulate NK Cell Function to Create an Immune-Tolerant Microenvironment
V. D. Gonzalez, Y.-W. Huang, S.-Y. Chen, A. Delgado-Gonzalez, K. Donoso, A. Gentles, K. Sachs, E. Porpiglia, W. Fantl
This study identifies CD9 as a novel therapeutic target in high-grade serous ovarian cancer by showing tumor cells modulate NK cell function through trogocytosis.
bioRxiv · Nov 20, 2020Immunology