S.-Y. Chen

Engineered Nanotopographies Induce Transient Openings in the Nuclear Membrane

This study shows that engineered nanotopographies create temporary nuclear membrane openings, enabling molecular exchange without cell penetration.

Thymidine Phosphorylase Promotes the Formation of Abdominal Aortic Aneurysm in Mice Fed a Western Diet

This study shows that TYMP promotes abdominal aortic aneurysm (AAA) in mice fed a Western diet by enhancing inflammation, thrombosis, and MMP2 activation while inhibiting vascular smooth muscle cell function.

NINJ1 regulates ferroptosis via xCT antiporter interaction and CoA modulation

This paper shows NINJ1 protects cancer cells from ferroptosis by interacting with xCT antiporter and modulating CoA and GSH levels.

The effects of resistance training on denervated myofibers, senescent cells, and associated protein markers in middle-aged adults

This study examines how resistance training affects denervated myofibers, senescent cells, and related proteins in middle-aged adults, finding increased muscle-nerve communication proteins but no significant changes in senescent cell content or SASP proteins.

APP substrate ectodomain defines A beta length by restraining gamma-secretase processivity and facilitating product release

The paper investigates how the APP ectodomain regulates gamma-secretase processivity and A beta peptide length, identifying it as a target for Alzheimer's disease therapies.

Hydrogen Sulfide Coordinates Glucose Metabolism Switch through Destabilizing Tetrameric Pyruvate Kinase M2

This study shows hydrogen sulfide destabilizes PKM2 tetramer through sulfhydration at cysteine 326, rewiring glucose metabolism and inhibiting tumor growth.

A novel deep proteomic approach in human skeletal muscle unveils distinct molecular signatures affected by aging and resistance training

This study uses a novel deep proteomic approach to analyze aging and resistance training effects on skeletal muscle proteomes, revealing distinct molecular changes in myofibrillar and non-myofibrillar fractions.

ApoA-I Protects Pancreatic β-cells from Cholesterol-induced Mitochondrial Damage and Restores their Ability to Secrete Insulin

This study shows apoA-I improves β-cell insulin secretion by reducing oxidative stress and enhancing mitochondrial function in cholesterol-loaded cells.

Surfactant protein A promotes atherosclerosis through mediating macrophage foam cell formation

This study shows that surfactant protein A promotes atherosclerosis by enhancing macrophage foam cell formation through increased CD36 expression.

ERK-dependent DICER1 phosphorylation promotes open chromatin state and lineage plasticity to mediate tumor progression

The paper shows that phosphorylated DICER1 promotes open chromatin and lineage plasticity in lung adenocarcinomas, independent of miRNAs and EMT.

True-to-scale DNA-density maps correlate with major accessibility differences between active and inactive chromatin

The paper presents true-to-scale DNA-density maps of human and mouse nuclei, revealing significant accessibility differences between active and inactive compartments.

Active site geometry stabilization of a presenilin homolog by the lipid bilayer promotes intramembrane proteolysis

This study shows that the lipid bilayer stabilizes the active site geometry of the intramembrane protease PSH, enhancing its catalytic activity compared to micelles.

A Human Multi-Lineage Hepatic Organoid Model for Liver Fibrosis

This study develops a human hepatic organoid model of ARPKD liver fibrosis, showing that the ARPKD mutation leads to fibrosis through TGFβ and PDGFRB pathways.

Robust designation of meiotic crossover sites by CDK-2 through phosphorylation of the MutSγ complex

The paper shows CDK-2 phosphorylates MSH-5 to promote crossover formation during meiosis by enhancing recruitment of crossover-promoting complexes.

Tissue-resident, extravascular CD64-Ly6C- population forms a critical barrier for inflammation in the synovium

The paper identifies and characterizes two distinct synovial monocyte populations, showing that the extravascular population is critical for RA-like disease development.

AGL16 negatively modulates stress response to balance with growth

This study identifies AGL16 as a negative regulator that suppresses stress response genes to balance growth and stress tolerance in plants.

High-Grade Serous Ovarian Tumor Cells Modulate NK Cell Function to Create an Immune-Tolerant Microenvironment

This study identifies CD9 as a novel therapeutic target in high-grade serous ovarian cancer by showing tumor cells modulate NK cell function through trogocytosis.

Influenza-induced activation of recruited alveolar macrophages during the early inflammatory phase drives lung injury and lethality

This study identifies vimentin's role in driving pro-inflammatory responses in alveolar macrophages during influenza infection, linking it to lung injury and mortality.

Macrophages drive the inflammatory phase in experimental osteoarthritis

This study shows macrophages drive inflammation in early experimental osteoarthritis by expanding and altering their gene expression in mouse models.

Epigenetic therapy remodels the immune synaptic cytoskeleton to potentiate cancer susceptibility to γδ T cells

DNA methyltransferase inhibitors enhance γδ T cell-mediated lung cancer killing by remodeling immune synaptic cytoskeletal networks.

Activation of JUN in fibroblasts promotes pro-fibrotic programme and modulates protective immunity

This study shows JUN activation in fibroblasts drives fibrosis and modulates immunity, with therapeutic potential through targeting IL-6, CD47, and PD-L1.

Maintenance DNA methylation is essential for regulatory T cell development and stability of suppressive function

This study shows that maintenance DNA methylation, regulated by Uhrf1, is essential for Treg cell development and stability of their suppressive function.