T Cell Activation Triggers Reversible Inosine-5’-Monophosphate Dehydrogenase Assembly
K. Duong-Ly, Y.-M. Kuo, M. C. Johnson, J. Kollman, J. Soboloff, G. Rall, A. Andrews, J. Peterson
This study shows T cell activation leads to reversible IMPDH assembly into filaments, regulated by mTOR and STIM1, with implications for guanine nucleotide biosynthesis and T cell proliferation.
bioRxiv · May 16, 2018Immunology