J. Peterson

Generative Adversarial Networks Accurately Reconstruct Pan-Cancer Histology from Pathologic, Genomic, and Radiographic Latent Features

This paper introduces HistoXGAN, a GAN that reconstructs cancer histology from latent features, showing it retains tumor grade, histologic subtype, and gene expression patterns across 29 cancer types.

Multi-state occupancy model estimates probability of detection of an aquatic parasite using environmental DNA: Pseudoloma neurophilia in zebrafish aquaria

The paper develops a non-lethal method to detect Pseudoloma neurophilia in zebrafish aquaria using eDNA and a multi-state occupancy model to estimate detection probability under different flow conditions.

Toll-like receptor signalling via IRAK4 confers epithelial integrity and tightness through regulation of junctional tension

This study shows that TLR signaling via IRAK4 maintains epithelial tightness by regulating junctional tension in human intestinal cells.

Epigenomic characterization of latent HIV infection identifies latency regulating transcription factors.

This study identifies transcription factors regulating HIV latency through epigenomic analysis of latently infected cells.

Sex, androgens and regulation of pulmonary AR, TMPRSS2 and ACE2

This study investigates sex differences in TMPRSS2 and ACE2 expression in human and mouse lungs and evaluates the effect of anti-androgens on these genes, finding no significant increase in TMPRSS2 but sex dimorphism in ACE2.

Identifying conserved molecular targets required for cell migration of glioblastoma cancer stem cells

This study identifies Rap1a as a conserved regulator of glioblastoma cancer stem cell migration using a combination of Drosophila and human models.

SEMA4C is a novel target to limit osteosarcoma growth, progression, and metastasis

This study shows SEMA4C promotes osteosarcoma growth and metastasis, with its inhibition reducing tumor progression and suggesting clinical potential.

A metabolic switch from OXPHOS to glycolysis is essential for cardiomyocyte proliferation in the regenerating heart

This study identifies a metabolic switch from OXPHOS to glycolysis in regenerating zebrafish hearts, showing it is essential for cardiomyocyte proliferation and heart regeneration.

An In-Silico Mammalian Whole-Cell Model Reveals the Influence of Spatial Organization on RNA Splicing Efficiency

The paper develops a spatially-resolved whole HeLa cell model to study how spatial organization affects RNA splicing efficiency and particle assembly.

T Cell Activation Triggers Reversible Inosine-5’-Monophosphate Dehydrogenase Assembly

This study shows T cell activation leads to reversible IMPDH assembly into filaments, regulated by mTOR and STIM1, with implications for guanine nucleotide biosynthesis and T cell proliferation.