Major Histocompatibility Complex (MHC) I-induced Endoplasmic Reticulum (ER) Stress mediates the secretion of pro-inflammatory muscle-derived cytokines
A. Thoma, K. E. Earl, R. G. Cooper, K. Goljanek-Whysall, A. P. Lightfoot
This study shows that MHC I overexpression in muscle cells induces ER stress, leading to pro-inflammatory cytokine release, which is reduced by salubrinal.
bioRxiv · Jun 29, 2022Cell Biology