TK216 targets microtubules in Ewing sarcoma cells
J. M. Povedano Selfa, V. Li, K. E. Lake, X. Bai, R. Rallabandi, J. Kim, Y. Xie, J. K. De Brabander, D. G. McFadden
This study identifies TK216 as a microtubule destabilizing agent that causes cytotoxicity in Ewing sarcoma cells, explaining its synergy with vincristine and suggesting reevaluation of its clinical trials.
bioRxiv · Nov 19, 2021Cancer Biology