D. G. McFadden

Forward genetic screens identify mechanisms of resistance to small molecule lactate dehydrogenase inhibitors

This study identifies two resistance mechanisms to LDH inhibitors in complex I-mutant HTC models through forward genetic screens.

Inducible mismatch repair streamlines forward genetic approaches to target identification of cytotoxic small molecules

This study develops an inducible mismatch repair system to identify targets of orphan cytotoxins by screening for compound resistance mutations in engineered cell lines.

Treatment with anti-inflammatory viral serpin modulates immuno-thrombotic responses and improves outcomes in SARS-CoV-2 infected mice

This study shows that PEGSerp-1 treatment reduces inflammation and improves outcomes in SARS-CoV-2 infected mice by modulating immuno-thrombotic responses.

Mitochondrial-encoded complex I impairment induces a targetable dependency on aerobic fermentation in Hürthle cell carcinoma of the thyroid

This study shows that mitochondrial complex I defects in thyroid cancer drive reliance on aerobic fermentation, which can be targeted with lactate dehydrogenase inhibitors.

TK216 targets microtubules in Ewing sarcoma cells

This study identifies TK216 as a microtubule destabilizing agent that causes cytotoxicity in Ewing sarcoma cells, explaining its synergy with vincristine and suggesting reevaluation of its clinical trials.

Differential requirements for mitochondrial electron transport chain components in the adult murine liver

This study investigates the tissue-specific roles of mitochondrial complex I and IV in adult mouse liver, finding that complex I loss is tolerated while complex IV dysfunction causes metabolic and functional impairments.