V. Li

Persistent cross-species transmission systems dominate Shiga toxin-producing Escherichia coli O157:H7 epidemiology in a high incidence region: a genomic epidemiology study

This study identifies persistent cross-species transmission systems between cattle and humans as a major driver of E. coli O157:H7 epidemiology in Alberta, with a shift toward more virulent stx2a-only strains.

An engineered human cardiac tissue model reveals contributions of systemic lupus erythematosus autoantibodies to myocardial injury

This study uses engineered human cardiac tissues to show how SLE autoantibodies affect myocardial injury through distinct binding patterns and functional effects on cardiac cells.

Mixed Alkyl/Aryl Phosphonates Identify Metabolic Serine Hydrolases as Antimalarial Targets

The paper identifies mixed alkyl/aryl phosphonates as anti-malarial compounds that inhibit serine hydrolases with low resistance potential.

Competition-driven eco-evolutionary feedback reshapes bacteriophage lambda's fitness landscape and enables speciation

This study shows how fitness landscapes change during adaptation, enabling speciation by opening new adaptive pathways in bacteriophage lambda.

A Cell Cycle-Dependent Ferroptosis Sensitivity Switch Governed by EMP2

The paper shows cell cycle arrest increases sensitivity to GPX4 inhibitor-induced ferroptosis via elevated oxidizable phospholipids and reduced EMP2 expression.

Overexpressed Malat1 Drives Metastasis through Inflammatory Reprogramming of Lung Adenocarcinoma Microenvironment

This study shows that overexpressed Malat1 promotes lung adenocarcinoma metastasis by reprogramming the tumor microenvironment through Ccl2-driven inflammation.

Stabilisation of β-Catenin-WNT signalling by USP10 in APC-truncated colorectal cancer drives cancer stemness and enables super-competitor signalling

This study identifies USP10 as a deubiquitylase that stabilizes β-Catenin in APC-truncated colorectal cancer, enhancing WNT signaling and cancer stemness.

Mitochondrial-encoded complex I impairment induces a targetable dependency on aerobic fermentation in Hürthle cell carcinoma of the thyroid

This study shows that mitochondrial complex I defects in thyroid cancer drive reliance on aerobic fermentation, which can be targeted with lactate dehydrogenase inhibitors.

TK216 targets microtubules in Ewing sarcoma cells

This study identifies TK216 as a microtubule destabilizing agent that causes cytotoxicity in Ewing sarcoma cells, explaining its synergy with vincristine and suggesting reevaluation of its clinical trials.

Diverse viruses in deep-sea hydrothermal vent fluids have restricted dispersal across ocean basins

This study examines viral diversity and host interactions in deep-sea hydrothermal vent fluids, finding that viruses are diverse but have restricted dispersal and narrow host ranges.