Author

K. E. Nowakowski

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Immunology· 1

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Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

A. D. Badley· 1 shared A. Wu· 1 shared G. Ruan· 1 shared H. Dong· 1 shared J. P. Abeykoon· 1 shared J. Paludo· 1 shared K. A. Gwin· 1 shared M. K. Manske· 1 shared

Activity by Year

2021-2021 · peak 1/yr

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10 top collaborators · 45 mutual co-author links

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1 shared paperImmunology

A. D. Badley

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1 paper

Recent·Most cited

Secreted ORF8 is a pathogenic cause of severe Covid-19 and potentially targetable with select NLRP3 inhibitors

X. Wu, M. K. Manske, G. Ruan, T. L. Witter, K. E. Nowakowski, J. P. Abeykoon, X. Tang, Y. Yu, K. A. Gwin, A. Wu, V. Taupin, V. Bhardwaj, J. Paludo, S. Dasari, H. Dong, , T. E. Witzig

This study identifies ORF8 as a secreted glycoprotein that drives severe COVID-19 through NLRP3 inflammasome activation and shows it is inhibited by MCC950.

bioRxiv · Dec 2, 2021Immunology