Author

A. D. Badley

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Evolutionary Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Assay:proteomics· 2 Approach:statistical model· 2

Frequent Co-Authors

A. Herschhorn· 1 shared A. Pagliuzza· 1 shared A. T. Haase· 1 shared A. Venkatakrishnan· 1 shared A. Wu· 1 shared B. Howell· 1 shared C. Dobrowolski· 1 shared C. Reilly· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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Curved chords = mutual co-authorship

1 shared paperImmunology

A. Herschhorn

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

KDM5A/B promotes HIV-1 latency and KDM5 inhibitors promote HIV-1 lytic reactivation

T.-W. Li, D. Zhou, Z. Wu, G. N. Fiches, X. Wang, Y. Park, W. Jiang, W.-Z. Ho, A. D. Badley, N. G. Santoso, J. Qi, J. Zhu

This study shows that KDM5A/B promote HIV-1 latency and their inhibition with JQKD82, combined with AZD5582, reactivates HIV-1 and induces cell death.

bioRxiv · Nov 17, 2022 · PreprintMicrobiology

Detecting sources of immune activation and viral rebound in HIV infection

S. Wietgrefe, L. Duan, J. Anderson, G. Marques, M. Sanders, N. W. Cummins, A. D. Badley, C. Dobrowolski, J. Karn, A. Pagliuzza, N. Chomont, G. Sannier, M. Dube, D. E. Kaufmann, P. Zuck, , A. T. Haase

The paper compares assays for detecting HIV-producing cells and p24 during ART to identify sources of immune activation and viral rebound.

bioRxiv · Jun 8, 2022Immunology

Secreted ORF8 is a pathogenic cause of severe Covid-19 and potentially targetable with select NLRP3 inhibitors

X. Wu, M. K. Manske, G. Ruan, T. L. Witter, K. E. Nowakowski, J. P. Abeykoon, X. Tang, Y. Yu, K. A. Gwin, A. Wu, V. Taupin, V. Bhardwaj, J. Paludo, S. Dasari, H. Dong, , T. E. Witzig

This study identifies ORF8 as a secreted glycoprotein that drives severe COVID-19 through NLRP3 inflammasome activation and shows it is inhibited by MCC950.

bioRxiv · Dec 2, 2021Immunology

Multi-pronged human protein mimicry by SARS-CoV-2 reveals bifurcating potential for MHC detection and immune evasion

A. Venkatakrishnan, N. Kayal, P. Anand, A. D. Badley, G. M. Church, V. Soundararajan

This study identifies 33 SARS-CoV-2 peptides that mimic human proteins, revealing potential for immune evasion and MHC detection.

bioRxiv · Jun 19, 2020Evolutionary Biology