Author

S. Dasari

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biochemistry· 1 Cancer Biology· 1 Cell Biology· 1 Immunology· 1 Physiology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 3 Organism:human· 3 Assay:proteomics· 3 Research Focus:host-pathogen & immune response· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

A. C. Diaz· 1 shared A. D. Badley· 1 shared A. D. Pellegrini· 1 shared A. Ganesan· 1 shared A. K. Mitra· 1 shared A. M. Cirrincione· 1 shared A. U. Fayyaz· 1 shared A. Wu· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 8 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

1 shared paperCell Biology

A. C. Diaz

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Epidermal Eg5 promotes X-ROS dependent paclitaxel neurotoxicity

A. C. Diaz, A. M. Cirrincione, N. A. Schmidt, M. J. Ugo, M. C. A. Sanchez, C. A. Reimonn, S. Wuchty, A. D. Pellegrini, L. R. Rude, L. G. Pappalardo, D. P. Regan, C. Howell, S. Hrstka, S. Dasari, T. S. Lisse, , S. Rieger

The paper shows paclitaxel induces microtubule modifications in keratinocytes, leading to neurotoxicity via X-ROS and MMP-13, with Eg5 playing a key role.

bioRxiv · May 22, 2023 · PreprintCell Biology

Cancer associated fibroblasts serve as an ovarian cancer stem cell niche through noncanonical Wnt5a signaling

Y. Fang, X. Xiao, J. Wang, S. Dasari, D. Pepin, K. Nephew, D. Zamarin, A. K. Mitra

This study shows that cancer-associated fibroblasts maintain ovarian cancer stem cells via noncanonical Wnt5a signaling, which contributes to chemoresistance and relapse.

bioRxiv · Feb 28, 2023Cancer Biology

The H163A Mutation Unravels an Oxidized Conformation of the SARS-CoV-2 Main Protease and Opens a New Avenue for Anti-Viral Therapeutic Design

N. Tran, S. Dasari, S. Barwell, M. McLeod, S. Kalyaanamoorthy, T. Holyoak, A. Ganesan

This study identifies an oxidized conformation of SARS-CoV-2 Mpro through a point mutation and suggests it could inform new antiviral strategies.

bioRxiv · Dec 16, 2022 · PreprintBiochemistry

Secreted ORF8 is a pathogenic cause of severe Covid-19 and potentially targetable with select NLRP3 inhibitors

X. Wu, M. K. Manske, G. Ruan, T. L. Witter, K. E. Nowakowski, J. P. Abeykoon, X. Tang, Y. Yu, K. A. Gwin, A. Wu, V. Taupin, V. Bhardwaj, J. Paludo, S. Dasari, H. Dong, , T. E. Witzig

This study identifies ORF8 as a secreted glycoprotein that drives severe COVID-19 through NLRP3 inflammasome activation and shows it is inhibited by MCC950.

bioRxiv · Dec 2, 2021Immunology

Histologic and Proteomic Remodeling of the Pulmonary Veins and Arteries in a Porcine Model of Chronic Pulmonary Venous Hypertension

A. U. Fayyaz, M. S. Sabbah, S. Dasari, L. G. Griffiths, H. M. DeBrock, M. C. Charlesworth, B. A. Borlaug, S. M. Jenkins, W. D. Edwards, M. M. Redfield

This paper identifies proteomic and signaling differences between pulmonary veins and arteries in a porcine model of chronic pulmonary venous hypertension, revealing unique endothelial barrier dysfunction and EndoMT in veins.

bioRxiv · Mar 26, 2021Physiology