Hepatic FGF21 mediates tissue tolerance during bacterial inflammation by preserving cardiac function
S. C. Huen, A. Wang, K. Feola, R. Desrouleaux, H. H. Luan, R. Hogg, C. Zhang, Q.-J. Zhang, Z.-P. Liu, R. Medzhitov
This study shows that hepatic FGF21 promotes survival during bacterial inflammation by preserving cardiac function, and its signaling via beta-Klotho is required for this protective effect.
Journal of Experimental Medicine · Aug 18, 2021Peer-reviewedImmunology