Author

K. Fiedorczuk

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:cryo-EM· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:clustering· 1 Research Focus:differential expression· 1 Organism:mouse· 1

Frequent Co-Authors

J. Chen· 2 shared A. Chudnovskiy· 1 shared A. M. Bilate· 1 shared D. Mucida· 1 shared E. Fuchs· 1 shared G. D. Victora· 1 shared G. Pasqual· 1 shared J. Bilanovic· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersBiophysics

J. Chen

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Author profile →

3 papers

Recent·Most cited

Structural basis for CFTR inhibition by CFTRinh-172

P. Young, J. Levring, K. Fiedorczuk, S. C. Blanchard, J. Chen

This paper determines the structure of CFTR bound to CFTRinh-172 using cryo-EM, revealing its dual role as a pore blocker and gating modulator.

bioRxiv · Oct 11, 2023 · PreprintBiophysics

Universal recording of cell-cell contacts in vivo for interaction-based transcriptomics

S. Nakandakari-Higa, M. C. C. Canesso, S. Walker, A. Chudnovskiy, J. Bilanovic, J. T. Jacobsen, S. M. Parigi, K. Fiedorczuk, E. Fuchs, A. M. Bilate, G. Pasqual, D. Mucida, Y. Pritykin, G. D. Victora

The paper introduces uLIPSTIC, a universal method to record cell-cell interactions in vivo, and combines it with single-cell transcriptomics to study immune cell interactions with intestinal epithelial cells.

bioRxiv · Mar 16, 2023Immunology

Mechanism of CFTR correction by type I folding correctors

J. Chen, K. Fiedorczuk

This study determines the mechanism by which two FDA-approved CFTR correctors stabilize the misfolded ΔF508 mutant by binding to a hydrophobic pocket in TMD1.

bioRxiv · Jun 18, 2021Biophysics