G. D. Victora

Mosaic sarbecovirus nanoparticles elicit cross-reactive responses in pre-vaccinated animals

The paper shows mosaic-8b nanoparticles induce broader cross-reactive antibodies than homotypic ones, even in pre-vaccinated animals, suggesting potential for improved vaccine design against emerging sarbecoviruses.

Opposing effects of pre-existing antibody and memory T cell help on the dynamics of recall germinal centers

This study investigates how pre-existing antibodies and memory T cell help influence the dynamics of recall germinal centers, showing that pre-existing antibodies suppress antigen binding while memory T cells enable B cells to access GCs despite low antigen binding.

Suppression of epithelial proliferation and tumorigenesis by immunoglobulin A

This study shows that IgA suppresses epithelial proliferation and tumorigenesis by interacting with DMBT1, highlighting its role in maintaining mucosal homeostasis.

Universal recording of cell-cell contacts in vivo for interaction-based transcriptomics

The paper introduces uLIPSTIC, a universal method to record cell-cell interactions in vivo, and combines it with single-cell transcriptomics to study immune cell interactions with intestinal epithelial cells.

Identification of dendritic cell-T cell interactions driving immune responses to food

This study identifies dendritic cell subsets that drive immune responses to dietary antigens, showing that cDC1s induce regulatory T cells while cDC2s promote pro-inflammatory responses.

Proximity-dependent labeling identifies dendritic cells that drive the tumor-specific CD4+ T cell response

The paper identifies dendritic cells that present antigens to CD4+ T cells in tumor-draining lymph nodes and the tumor microenvironment using LIPSTIC-based single-cell transcriptomics.

Molecular fate-mapping of serum antibodies reveals the effects of antigenic imprinting on repeated immunization

This study uses molecular fate-mapping to show that repeated immunization preferentially reuses initial B cell clones over recruiting new ones, with imprinting effects decreasing as antigenic distance increases.

Human anti-ACE2 monoclonal antibodies as pan-sarbecovirus prophylactic agents

The paper develops human monoclonal antibodies targeting the ACE2 receptor to block infection by SARS-CoV-2 and related sarbecoviruses, showing broad efficacy against variants and no adverse effects on ACE2 function.

Sustained antibody response to ZIKV infection induced by NS1 protein is accompanied by the progressive appearance of autoreactive antibodies and cross-reactive B cell clones.

The paper investigates the humoral immune response to Zika virus NS1, showing its immunodominance and association with autoreactive and cross-reactive B cell clones.

Cyclin D3 drives inertial cell cycling in dark zone germinal center B cells

This study identifies cyclin D3 as essential for inertial cell cycling in dark zone germinal center B cells, enabling clonal expansion and linking it to potential lymphoproliferative disorders.

T cell receptor is required for differentiation but not maintenance of intestinal intraepithelial lymphocytes

One-step generation of monoclonal B cell receptor mice capable of class switch recombination and somatic hypermutation

This paper describes a method to generate monoclonal B cell receptor mice capable of somatic hypermutation and class switch recombination using CRISPR/Cas9.

Intestinal epithelial and intraepithelial T cell crosstalk mediates a dynamic response to infection

The paper investigates how intestinal epithelial cells and T cells interact during infection, showing that microbial sensing alters T cell behavior and metabolism to protect the intestinal barrier.