S. Nakandakari-Higa

The paper introduces uLIPSTIC, a universal method to record cell-cell interactions in vivo, and combines it with single-cell transcriptomics to study immune cell interactions with intestinal epithelial cells.

This study identifies dendritic cell subsets that drive immune responses to dietary antigens, showing that cDC1s induce regulatory T cells while cDC2s promote pro-inflammatory responses.

The paper identifies dendritic cells that present antigens to CD4+ T cells in tumor-draining lymph nodes and the tumor microenvironment using LIPSTIC-based single-cell transcriptomics.

The paper develops human monoclonal antibodies targeting the ACE2 receptor to block infection by SARS-CoV-2 and related sarbecoviruses, showing broad efficacy against variants and no adverse effects on ACE2 function.