Author

J. Levring

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:cryo-EM· 2 Research Focus:protein structure prediction· 2 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Assay:electrophysiology· 1 Assay:structural biology· 1

Frequent Co-Authors

J. Chen· 3 shared A. L. Kaplan· 1 shared B. K. Shoichet· 1 shared F. Liu· 1 shared H. L. Pietz· 1 shared I. S. Kondratov· 1 shared J. Einsiedel· 1 shared J. J. Irwin· 1 shared

Activity by Year

2023-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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3 shared papersBiophysics

J. Chen

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Author profile →

3 papers

Recent·Most cited

Structural basis for CFTR inhibition by CFTRinh-172

P. Young, J. Levring, K. Fiedorczuk, S. C. Blanchard, J. Chen

This paper determines the structure of CFTR bound to CFTRinh-172 using cryo-EM, revealing its dual role as a pore blocker and gating modulator.

bioRxiv · Oct 11, 2023 · PreprintBiophysics

Structural identification of a selectivity filter in CFTR

J. Levring, J. Chen

This study identifies the structure of the CFTR selectivity filter, revealing a chloride-binding site that defines ion selectivity and conductance.

bioRxiv · Oct 11, 2023Biophysics

Structure-based discovery of CFTR potentiators and inhibitors

F. Liu, A. L. Kaplan, J. Levring, J. Einsiedel, S. Tiedt, K. Distler, N. Omattage, I. S. Kondratov, Y. S. Moroz, H. L. Pietz, J. J. Irwin, P. Gmeiner, B. K. Shoichet, J. Chen

The paper identifies novel CFTR modulators using molecular docking, electrophysiology, cryo-EM, and medicinal chemistry, discovering potentiators and inhibitors with mid-nanomolar activity.

bioRxiv · Sep 9, 2023Biophysics