Alternative Complement Pathway Regulates Thermogenic Fat Function via Adipsin and Adipocyte-derived C3aR1 in a Sex-dependent Fashion
L. Ma, A. Gilani, A. Rubio-Navarro, E. Cortada, A. Li, S. M. Reilly, L. Tang, J. C. Lo
This study shows that the alternative complement pathway, via Adipsin and C3aR1, regulates adipose thermogenesis with sex-dependent effects, impacting energy expenditure and metabolic health.
bioRxiv · Dec 30, 2022 · PreprintCell Biology