K. Halvorsen

High-throughput single-molecule quantification of individual base stacking energies in nucleic acids

This study measures individual base stacking energies in DNA and RNA using a custom Centrifuge Force Microscope, finding stronger stacking between purines and weaker between pyrimidines, with implications for DNA nanostructures, enzymatic ligation, and MD simulations.

Detection of Alzheimer's associated microRNAs using a DNA-based smart reagent

This paper develops a DNA-based assay to detect Alzheimer's-associated microRNAs with high sensitivity and specificity, demonstrating its potential as a diagnostic tool.

DNA nanoswitch barcodes for multiplexed biomarker profiling

This paper introduces DNA nanoswitch barcodes for multiplexed detection of up to 6 biomarkers in a single assay, demonstrating mixed multiplexing of DNA, RNA, antibody, and protein.

The consequences of size-selective fishing mortality for larval production and sustainable yield in species with obligate male care

This study examines how size-based fishing management interacts with mating systems in species with obligate male care, finding that slot limits can reduce yield less than minimum size limits under certain conditions.

Programmable low-cost DNA-based platform for viral RNA detection

This paper develops a low-cost DNA-based platform for rapid and sensitive detection of viral RNA, demonstrating its effectiveness with Zika and SARS-CoV-2 as model systems.

Exceptional biostability of paranemic crossover (PX) DNA, crossover-dependent nuclease resistance, and implications for DNA nanotechnology

The paper investigates the nuclease resistance and biostability of PX DNA, finding it significantly more resistant to degradation than double-stranded DNA and suggesting its potential for enhancing DNA nanotechnology.

Detection of cellular microRNAs with programmable DNA nanoswitches

This paper introduces miRacles, a DNA nanoswitch-based assay for detecting microRNAs with high sensitivity and specificity, offering a rapid, cost-effective alternative to traditional methods.