S. Charles

Non-Invasive Quality Control of Organoid Cultures Using Mesofluidic CSTR Bioreactors and High-Content Imaging

This paper develops a mesofluidic bioreactor platform with high-content imaging for non-invasive quality control of brain organoids, improving their development and reducing cell death.

hb or not hb - when and why accounting for background mortality in toxicological survival models matters?

This study evaluates the impact of estimating background mortality (hb) in toxicological survival models on LC50 accuracy and model parameter estimates.

Ongoing emergence of M1UK lineage among invasive group A streptococcus isolates in 2020 and use of allele-specific PCR

The paper develops an allele-specific PCR to subtype emm1 Streptococcus pyogenes isolates, finding M1UK lineage dominates invasive infections in England in 2020.

Drivers of mangrove vulnerability and resilience to tropical cyclones in the North Atlantic Basin

The paper analyzes mangrove vulnerability and resilience to tropical cyclones in the North Atlantic Basin using 25 years of remote sensing data and machine learning to identify regional and subregional drivers.

Multi-scale observations of mangrove blue carbon fluxes; the NASA Carbon Monitoring System BlueFlux field campaign

The paper describes the BlueFlux field campaign, which measures CO2 and CH4 fluxes in mangroves using multiple methods and scales them to gridded products to improve climate change mitigation strategies.

Chemical effects on ecological interactions within a model-experiment loop

The paper develops a dynamic model to assess contaminant effects on a micro-ecosystem and uses Bayesian inference to estimate parameters from experimental data, identifying direct and indirect ecological impacts of cadmium.

Generic solving of physiologically-based kinetic models in support of next generation risk assessment due to chemicals

This paper presents a unified framework for solving Physiologically-Based Kinetic (PBK) models using matrix ordinary differential equations, enabling flexible modeling of chemical absorption, distribution, metabolism, and excretion across organisms.

Improvements in estimating bioaccumulation metrics in the light of toxicokinetics models and Bayesian inference

This paper improves bioaccumulation metric estimation by using Bayesian inference and a meta-analysis of toxicokinetic data to propose using the 75th percentile of uncertainty intervals for classification.

Emergence of Heartbeat Frailty in Advanced Age: Perspectives from Life-Long EKG Recordings in Mice

This study tracks EKG recordings in mice to identify age-related changes in heart rhythm variability, linking them to signs of cardiac and systemic frailty in advanced age.

'rbioacc': an R-package to analyse toxicokinetic data

rbioacc is an R-package that analyzes toxicokinetic data from bioaccumulation tests, providing Bayesian parameter estimates and bioaccumulation metrics with uncertainty.

Generic solving of one-compartment toxicokinetic models

This paper provides the analytical solution for one-compartment toxicokinetic models, enabling better parameter estimation and environmental risk assessment.

Accumulation-depuration data collection in support of toxicokinetic modelling

The paper collects and provides raw toxicokinetic data from scientific literature to support TK modelling via the MOSAICbioacc web application.

morse: an R-package in support of Environmental Risk Assessment

The paper introduces the morse R-package for analyzing toxicity test data to estimate environmental risk indices in compliance with regulatory guidelines.

Taking full advantage of modelling to better assess environmental risk due to xenobiotics

The paper reviews dose-response models and introduces MOSAIC, a tool for environmental risk assessment using TKTD models to improve pesticide risk evaluation for aquatic organisms.

TKTDsimulation.jl and tktdjl2r: innovative packages for High Performance Computing of survival predictions in support of environmental risk assessment under time-variable scenarios

New perspectives on the calculation of bioaccumulation metrics for active substances in living organisms

The paper introduces a web tool, MOSAICbioacc, for calculating bioaccumulation metrics with uncertainty, designed to assist ecotoxicologists and regulators in analyzing complex exposure scenarios.

How to account for the uncertainty from standard toxicity tests in species sensitivity distributions: an example in non-target plants

This paper assesses how uncertainty in ER50 values affects HR5 estimates in SSD analyses for non-target plants using Bayesian and frequentist methods.

Programmable low-cost DNA-based platform for viral RNA detection

This paper develops a low-cost DNA-based platform for rapid and sensitive detection of viral RNA, demonstrating its effectiveness with Zika and SARS-CoV-2 as model systems.

Recommendations to address uncertainties in environmental risk assessment using toxicokinetics-toxicodynamics models

This paper recommends using toxicokinetics-toxicodynamics models and Bayesian frameworks to improve the reliability of environmental risk assessments by addressing uncertainties in toxicity endpoint calculations.