Author

A. R. Chandrasekaran

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 6 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Research Focus:differential expression· 3 Assay:DNA methylation· 3 Assay:proteomics· 3 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

K. Halvorsen· 6 shared J. Vilcapoma· 3 shared B. K. Dey· 2 shared J. A. Punnoose· 2 shared L. Zhou· 2 shared M. MacIsaac· 2 shared O. Levchenko· 2 shared P. Dey· 2 shared

Activity by Year

2018-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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6 shared papersBioengineering

K. Halvorsen

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Author profile →

7 papers

Recent·Most cited

The unusual structural properties and potential biological relevance of switchback DNA

B. R. Madhanagopal, H. Talbot, A. Rodriguez, J. M. Louis, H. Zeghal, S. Vangaveti, K. Reddy, A. R. Chandrasekaran

This study characterizes switchback DNA, a left-handed DNA structure, showing its unique stability, nuclease resistance, and potential biological role in tandem repeats.

bioRxiv · Nov 15, 2023 · PreprintBioengineering

High-throughput single-molecule quantification of individual base stacking energies in nucleic acids

J. A. Punnoose, K. J. Thomas, A. R. Chandrasekaran, J. Vilcapoma, A. Hayden, K. Kilpatrick, S. Vangaveti, A. Chen, T. Banco, K. Halvorsen

This study measures individual base stacking energies in DNA and RNA using a custom Centrifuge Force Microscope, finding stronger stacking between purines and weaker between pyrimidines, with implications for DNA nanostructures, enzymatic ligation, and MD simulations.

bioRxiv · May 25, 2022Biophysics

Detection of Alzheimer's associated microRNAs using a DNA-based smart reagent

A. R. Chandrasekaran, K. Halvorsen

This paper develops a DNA-based assay to detect Alzheimer's-associated microRNAs with high sensitivity and specificity, demonstrating its potential as a diagnostic tool.

bioRxiv · Jun 1, 2021Bioengineering

DNA nanoswitch barcodes for multiplexed biomarker profiling

A. R. Chandrasekaran, M. MacIsaac, J. Vilcapoma, C. H. Hansen, D. Yang, W. P. Wong, K. Halvorsen

This paper introduces DNA nanoswitch barcodes for multiplexed detection of up to 6 biomarkers in a single assay, demonstrating mixed multiplexing of DNA, RNA, antibody, and protein.

bioRxiv · Sep 22, 2020Bioengineering

Programmable low-cost DNA-based platform for viral RNA detection

L. Zhou, A. R. Chandrasekaran, J. A. Punnoose, G. Bonenfant, S. Charles, O. Levchenko, P. Badu, C. Cavaliere, C. T. Pager, K. Halvorsen

This paper develops a low-cost DNA-based platform for rapid and sensitive detection of viral RNA, demonstrating its effectiveness with Zika and SARS-CoV-2 as model systems.

bioRxiv · Jan 12, 2020Bioengineering

Exceptional biostability of paranemic crossover (PX) DNA, crossover-dependent nuclease resistance, and implications for DNA nanotechnology

A. R. Chandrasekaran, J. Vilcapoma, P. Dey, S. W. Wong-Deyrup, B. K. Dey, K. Halvorsen

The paper investigates the nuclease resistance and biostability of PX DNA, finding it significantly more resistant to degradation than double-stranded DNA and suggesting its potential for enhancing DNA nanotechnology.

bioRxiv · Jan 7, 2020Bioengineering

Detection of cellular microRNAs with programmable DNA nanoswitches

A. R. Chandrasekaran, M. MacIsaac, P. Dey, O. Levchenko, L. Zhou, M. Andres, B. K. Dey, K. Halvorsen

This paper introduces miRacles, a DNA nanoswitch-based assay for detecting microRNAs with high sensitivity and specificity, offering a rapid, cost-effective alternative to traditional methods.

bioRxiv · May 30, 2018Bioengineering