PKD autoinhibition in trans regulates activation loop autophosphorylation in cis
R. Reinhardt, K. Hirzel, G. Link, S. A. Eisler, T. Haegele, M. A. H. Parson, J. E. Burke, A. Hausser, T. A. Leonard
This study shows PKD is regulated by trans-autoinhibition followed by cis autophosphorylation, switching the kinase on by preventing re-autoinhibition.
bioRxiv · May 5, 2022Biochemistry