Author

T. A. Leonard

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 5

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:protein folding & dynamics· 4 Approach:biophysical modeling· 2 Research Focus:cell signaling & trafficking· 2 Assay:protein structure· 2 Organism:C. elegans· 1 Research Focus:chromatin & epigenetic regulation· 1 Organism:human· 1

Frequent Co-Authors

J. E. Burke· 4 shared L. Truebestein· 3 shared K. D. Fleming· 2 shared A. Hausser· 1 shared A. L. Shaw· 1 shared A. Levina· 1 shared A.-C. Gavin· 1 shared C. Gehin· 1 shared

Activity by Year

2021-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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4 shared papersBiochemistry

J. E. Burke

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Author profile →

5 papers

Recent·Most cited

ATP-competitive and allosteric inhibitors induce differential conformational changes at the auto-inhibitory interface of Akt

A. L. Shaw, M. A. Parson, L. Truebestein, M. L. Jenkins, T. A. Leonard, J. E. Burke

This study investigates how ATP-competitive and allosteric inhibitors induce different conformational changes in Akt's auto-inhibitory interface across various phosphorylation states.

bioRxiv · Jul 14, 2022 · PreprintBiochemistry

PKD autoinhibition in trans regulates activation loop autophosphorylation in cis

R. Reinhardt, K. Hirzel, G. Link, S. A. Eisler, T. Haegele, M. A. H. Parson, J. E. Burke, A. Hausser, T. A. Leonard

This study shows PKD is regulated by trans-autoinhibition followed by cis autophosphorylation, switching the kinase on by preventing re-autoinhibition.

bioRxiv · May 5, 2022Biochemistry

Structure and regulation of the Myotonic dystrophy kinase-Related Cdc42-binding Kinase

L. Truebestein, E. Waltenberger, C. Gehin, A.-C. Gavin, T. A. Leonard

The paper presents the structure and membrane-binding properties of C. elegans MRCK1, revealing its homodimeric conformation and interactions with phosphoinositides and Cdc42.

bioRxiv · Mar 11, 2022Biochemistry

Activation of the essential kinase PDK1 by phosphoinositide-driven autophosphorylation

A. Levina, K. D. Fleming, J. E. Burke, T. A. Leonard

This study reveals how PDK1 is activated by phosphoinositides through autophosphorylation via a dimer mechanism and PH domain regulation.

bioRxiv · Oct 8, 2021Biochemistry

In vitro reconstitution of Sgk3 activation by phosphatidylinositol-3-phosphate

D. Pokorny, L. Truebestein, K. D. Fleming, J. E. Burke, T. A. Leonard

This study shows that Sgk3 is activated by PI3P through conformational changes and reconstitutes this activation in vitro using Vps34-mediated PI3P synthesis on liposomes.

bioRxiv · Apr 13, 2021Biochemistry