Author

K. Hutchinson

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3 Biochemistry· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Research Focus:cell type annotation· 3 Approach:statistical model· 3 Assay:cryo-EM· 2 Approach:deep learning· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Assay:structural biology· 2

Frequent Co-Authors

A. Schlessinger· 4 shared A. A. Thomas· 1 shared A. C. Stone· 1 shared B. Zhang· 1 shared C. Clausen· 1 shared C. Grewer· 1 shared D. B. Silva· 1 shared D. Wacker· 1 shared

Activity by Year

2022-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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4 shared papersBiophysics

A. Schlessinger

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4 papers

Recent·Most cited

Mechanisms of Cholesterol Binding to LAT1

K. Hutchinson, A. Schlessinger

This study investigates cholesterol binding to LAT1 using computational methods, identifying key binding sites and their stabilizing effects on LAT1 structure and function.

bioRxiv · Jan 2, 2024 · PreprintBiophysics

Conserved allosteric inhibition mechanism in SLC1 transporters

Y. Dong, J. Wang, R.-A. Garibsingh, K. Hutchinson, Y. Shi, G. Eisenberg, X. Yu, A. Schlessinger, C. Grewer

This study investigates the conserved allosteric inhibition mechanism of SLC1 transporters EAAT1 and ASCT2 using cryo-EM, kinetic experiments, and computational modeling, showing that UCPH-101 inhibits EAAT1 and partially inhibits ASCT2 with lower affinity.

bioRxiv · Sep 21, 2022Biophysics

Describing Inhibitor Specificity for the Amino Acid Transporter LAT1 from Metainference Simulations

K. Hutchinson, D. B. Silva, J. Bohlke, C. Clausen, A. A. Thomas, M. Bonomi, A. Schlessinger

This study uses metainference MD simulations, molecular docking, and experiments to identify critical residues and druggable pockets in LAT1, leading to the discovery of new inhibitors.

bioRxiv · May 3, 2022Biophysics

Substrate Binding and Inhibition of the Anion Exchanger 1 Transporter

M. J. Capper, S. Yang, A. C. Stone, S. Vatansever, G. Zilberg, Y. K. Mathiharan, R. Habib, K. Hutchinson, A. Schlessinger, M. Mezei, R. Osman, B. Zhang, D. Wacker

The paper presents high-resolution cryo-EM structures of the full-length human AE1 transporter in various states, revealing substrate binding, inhibition mechanisms, and lipid/sterol binding sites.

bioRxiv · Feb 11, 2022Biochemistry