Author

C. Grewer

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Assay:cryo-EM· 2 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Approach:experimental assay· 1

Frequent Co-Authors

A. Schlessinger· 2 shared A. A. Garaeva· 1 shared C. Paulino· 1 shared D. J. Slotboom· 1 shared E. Ndaru· 1 shared G. Eisenberg· 1 shared J. Wang· 1 shared K. Hutchinson· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersBiophysics

A. Schlessinger

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2 papers

Recent·Most cited

Conserved allosteric inhibition mechanism in SLC1 transporters

Y. Dong, J. Wang, R.-A. Garibsingh, K. Hutchinson, Y. Shi, G. Eisenberg, X. Yu, A. Schlessinger, C. Grewer

This study investigates the conserved allosteric inhibition mechanism of SLC1 transporters EAAT1 and ASCT2 using cryo-EM, kinetic experiments, and computational modeling, showing that UCPH-101 inhibits EAAT1 and partially inhibits ASCT2 with lower affinity.

bioRxiv · Sep 21, 2022Biophysics

Structural basis for stereospecific inhibition of ASCT2 from rational design

R.-A. A. Garibsingh, E. Ndaru, A. A. Garaeva, M. Bonomi, D. J. Slotboom, C. Paulino, C. Grewer, A. Schlessinger

The paper rationally designs inhibitors for ASCT2 using computational modeling and cryo-EM, showing how stereospecific pockets can be exploited for drug discovery.

bioRxiv · May 29, 2020Biochemistry