Author

K. I. Weinberg

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:ATAC-seq· 1 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

M. Pavel-Dinu· 2 shared S. Mantri· 2 shared B. Dejene· 1 shared B. T. Dejene· 1 shared C. Lee· 1 shared C. Nicolas· 1 shared C. Sindhu· 1 shared C. T. Charlesworth· 1 shared

Activity by Year

2018-2018 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersBioengineering

M. Pavel-Dinu

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2 papers

Recent·Most cited

Gene Correction for SCID-X1 in Long-Term Hematopoietic Stem Cells

M. Pavel-Dinu, V. Wiebking, B. T. Dejene, W. Srifa, S. Mantri, C. Nicolas, C. Lee, G. Bao, E. J. Kildebeck, N. Punjya, C. Sindhu, M. A. Inlay, N. Saxena, S. S. DeRavin, H. Malech, , M. Porteus

This study corrects SCID-X1 in hematopoietic stem cells using CRISPR/Cas9, achieving high integration frequencies and low off-target effects, supporting clinical development.

bioRxiv · Aug 22, 2018Bioengineering

Identification of Pre-Existing Adaptive Immunity to Cas9 Proteins in Humans

C. T. Charlesworth, P. S. Deshpande, D. P. Dever, B. Dejene, N. Gomez-Ospina, S. Mantri, M. Pavel-Dinu, J. Camarena, K. I. Weinberg, M. H. Porteus

The paper detects pre-existing adaptive immunity to Cas9 proteins in humans, finding antibodies against both SaCas9 and SpCas9 and T-cells specific to SaCas9.

bioRxiv · Jan 5, 2018Immunology