Author

M. Pavel-Dinu

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Immunology· 2 Bioengineering· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:human· 4 Research Focus:cell type annotation· 3 Approach:genetic perturbation / CRISPR· 3 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Assay:scRNA-seq· 2 Assay:ATAC-seq· 1 Assay:CITE-seq· 1

Frequent Co-Authors

M. H. Porteus· 3 shared K. I. Weinberg· 2 shared S. Mantri· 2 shared Y. Nakauchi· 2 shared A. Awani· 1 shared A. DeVilbiss· 1 shared A. Sheikali· 1 shared B. Dejene· 1 shared

Activity by Year

2018-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersImmunology

M. H. Porteus

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Genetically Corrected RAG2-SCID Human Hematopoietic Stem CellsRestore V(D)J-Recombinase and Rescue Lymphoid Deficiency

M. Pavel-Dinu, C. L. Gardner, Y. Nakauchi, T. Kawai, O. M. Delmonte, B. Palterer, M. Bosticardo, F. Pala, S. Viel, H. L. Malech, H. Y. Ghanim, N. N. Bode, G. L. Kurgan, C. A. Vakulskas, A. Sheikali, , M. H. Porteus

This study corrects the RAG2 gene in human hematopoietic stem cells to restore V(D)J recombination and lymphoid development in RAG2-SCID patients.

bioRxiv · Jul 12, 2022Immunology

Reticular Dysgenesis-associated Adenylate Kinase 2 deficiency causes failure of myelopoiesis through disordered purine metabolism

W. Wang, A. DeVilbiss, M. Arreola, T. Mathews, Z. Zhao, M. Martin-Sandoval, G. Benegiamo, A. Awani, L. Goeminne, D. Dever, Y. Nakauchi, M. Pavel-Dinu, W. Al-Herz, L. Noratangelo, M. H. Porteus, , K. G. Weinacht

This study shows AK2 deficiency disrupts mitochondrial metabolism, causing purine metabolism disorder and myelopoiesis failure through AMP accumulation and NAD+ depletion.

bioRxiv · Jul 5, 2021 · PreprintCell Biology

Gene Correction for SCID-X1 in Long-Term Hematopoietic Stem Cells

M. Pavel-Dinu, V. Wiebking, B. T. Dejene, W. Srifa, S. Mantri, C. Nicolas, C. Lee, G. Bao, E. J. Kildebeck, N. Punjya, C. Sindhu, M. A. Inlay, N. Saxena, S. S. DeRavin, H. Malech, , M. Porteus

This study corrects SCID-X1 in hematopoietic stem cells using CRISPR/Cas9, achieving high integration frequencies and low off-target effects, supporting clinical development.

bioRxiv · Aug 22, 2018Bioengineering

Identification of Pre-Existing Adaptive Immunity to Cas9 Proteins in Humans

C. T. Charlesworth, P. S. Deshpande, D. P. Dever, B. Dejene, N. Gomez-Ospina, S. Mantri, M. Pavel-Dinu, J. Camarena, K. I. Weinberg, M. H. Porteus

The paper detects pre-existing adaptive immunity to Cas9 proteins in humans, finding antibodies against both SaCas9 and SpCas9 and T-cells specific to SaCas9.

bioRxiv · Jan 5, 2018Immunology