Author

K. Ingelshed

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Assay:CRISPR screen· 1 Research Focus:differential expression· 1 Organism:mouse· 1

Frequent Co-Authors

D. P. Lane· 2 shared F. Wermeling· 2 shared L. Jiang· 2 shared S. Sedimbi· 2 shared A. Lerma Clavero· 1 shared B. Vojtesek· 1 shared C. Bosdotter· 1 shared P. Kannan· 1 shared

Activity by Year

2021-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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2 shared papersCancer Biology

D. P. Lane

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Author profile →

2 papers

Recent·Most cited

MDM2 inhibitors, nutlin-3a and navtemadelin, retain efficacy in human and mouse cancer cells cultured in hypoxia

A. Lerma Clavero, P. Lafqvist Boqvist, K. Ingelshed, C. Bosdotter, S. Sedimbi, L. Jiang, F. Wermeling, B. Vojtesek, D. P. Lane, P. Kannan

This study shows that MDM2 inhibitors nutlin-3a and navtemadelin remain effective in hypoxic conditions in human and mouse cancer cells with wild-type p53, but not in mutant or null p53 cells.

bioRxiv · Oct 20, 2022Cancer Biology

CRISPR enriches for cells with mutations in a p53-related interactome, and this can be inhibited.

L. Jiang, K. Ingelshed, Y. Shen, S. V. Boddul, V. S. Iyer, Z. Kasza, S. Sedimbi, D. P. Lane, F. Wermeling

The paper shows that CRISPR enriches cells with p53-related mutations and demonstrates that transient p53 inhibition can suppress this effect.

bioRxiv · Mar 10, 2021 · PreprintCancer Biology