Cancer BiologybioRxiv
MDM2 inhibitors, nutlin-3a and navtemadelin, retain efficacy in human and mouse cancer cells cultured in hypoxia
A. Lerma Clavero, P. Lafqvist Boqvist, K. Ingelshed…·P. Kannan
This study shows that MDM2 inhibitors nutlin-3a and navtemadelin remain effective in hypoxic conditions in human and mouse cancer cells with wild-type p53, but not in mutant or null p53 cells.