Author

K. J. Lampi

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:protein folding & dynamics· 2 Approach:biophysical modeling· 1 Assay:electronic health records· 1 Organism:human· 1 Approach:microscopy & imaging analysis· 1 Assay:protein structure· 1

Frequent Co-Authors

A. N. Loes· 1 shared A. P. Miller· 1 shared C. J. Vetter· 1 shared C. Mundorff· 1 shared D. Thorn· 1 shared G. D. Warren· 1 shared J. A. Carver· 1 shared J. L. Harman· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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1 shared paperBiochemistry

A. N. Loes

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Author profile →

3 papers

Recent·Most cited

The α-crystallin chaperones undergo a quasi-ordered co-aggregation process in response to saturating client interaction

A. P. Miller, S. E. O'Neill, K. J. Lampi, S. L. Reichow

This study examines how α-crystallin chaperones undergo structured co-aggregation when interacting with clients, revealing a quasi-ordered process distinct from amorphous aggregation.

bioRxiv · Aug 15, 2023Biophysics

Accumulative deamidation of human lens protein γS-crystallin leads to partially unfolded intermediates with enhanced aggregation propensity

C. J. Vetter, D. Thorn, S. G. Wheeler, C. Mundorff, K. Halverson-Kolkind, J. A. Carver, L. L. David, K. J. Lampi

This study shows that deamidation of γS-crystallin at specific sites leads to protein destabilization, increased unfolding, and enhanced aggregation in cataractous lenses.

bioRxiv · Feb 21, 2020 · PreprintBiochemistry

Evolution of multifunctionality through a pleiotropic substitution in the innate immune protein S100A9

J. L. Harman, A. N. Loes, G. D. Warren, M. C. Heaphy, K. J. Lampi, M. J. Harms

The paper shows how a single mutation in S100A9 affects its proinflammatory activity and proteolytic resistance while leaving S100A8/S100A9 antimicrobial activity unchanged, enabling multifunctionality in mammals.

bioRxiv · Dec 5, 2019Biochemistry