Author

G. D. Warren

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1

Frequent Co-Authors

J. L. Harman· 2 shared M. J. Harms· 2 shared A. N. Loes· 1 shared H. Nagai· 1 shared J. N. Pruneda· 1 shared J. V. Nguyen· 1 shared K. J. Lampi· 1 shared M. C. Heaphy· 1 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersBiophysics

J. L. Harman

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3 papers

Recent·Most cited

Mechanism of Lys6 poly-ubiquitin specificity by the L. pneumophila deubiquitinase LotA

G. D. Warren, T. Kitao, T. G. Franklin, J. V. Nguyen, P. P. Geurink, T. Kubori, H. Nagai, J. N. Pruneda

This study identifies and characterizes the deubiquitinase domain of LotA from L. pneumophila that specifically targets K6-linked poly-ubiquitin during infection.

bioRxiv · May 11, 2022Biochemistry

Evolution avoids a pathological stabilizing interaction in the immune protein S100A9

J. L. Harman, P. N. Reardon, S. M. Costello, G. D. Warren, S. R. Phillips, P. J. Connor, S. Marqusee, M. J. Harms

The paper identifies a mutation in S100A9 that stabilizes a non-functional conformation, revealing an evolutionary constraint on stabilizing mutations.

bioRxiv · May 9, 2022 · PreprintBiophysics

Evolution of multifunctionality through a pleiotropic substitution in the innate immune protein S100A9

J. L. Harman, A. N. Loes, G. D. Warren, M. C. Heaphy, K. J. Lampi, M. J. Harms

The paper shows how a single mutation in S100A9 affects its proinflammatory activity and proteolytic resistance while leaving S100A8/S100A9 antimicrobial activity unchanged, enabling multifunctionality in mammals.

bioRxiv · Dec 5, 2019Biochemistry