Author

J. L. Harman

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Biochemistry· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Organism:human· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

G. D. Warren· 2 shared M. J. Harms· 2 shared A. Finigan· 1 shared A. K. Uryga· 1 shared A. L. Taylor· 1 shared A. N. Loes· 1 shared C. A. Pellet-Many· 1 shared H. Jorgensen· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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2 shared papersBiophysics

G. D. Warren

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Author profile →

4 papers

Recent·Most cited

Macrophage-expressed Neuropilin 2 promotes plaque formation in ApoE knockout mice and is essential for pro-inflammatory macrophage polarisation and gene expression.

J. Fernando-Sayers, J. L. Harman, M. C. Gage, I. C. Zachary, C. A. Pellet-Many

This study shows that macrophage-expressed Neuropilin 2 promotes atherosclerosis by enhancing pro-inflammatory polarization and plaque formation in ApoE knockout mice.

bioRxiv · Sep 27, 2023 · PreprintCell Biology

Evolution avoids a pathological stabilizing interaction in the immune protein S100A9

J. L. Harman, P. N. Reardon, S. M. Costello, G. D. Warren, S. R. Phillips, P. J. Connor, S. Marqusee, M. J. Harms

The paper identifies a mutation in S100A9 that stabilizes a non-functional conformation, revealing an evolutionary constraint on stabilizing mutations.

bioRxiv · May 9, 2022 · PreprintBiophysics

Primed smooth muscle cells acting as first responder cells in disease

M. D. Worssam, J. Lambert, S. Oc, A. L. Taylor, L. Dobnikar, J. Chappell, J. L. Harman, N. L. Figg, A. Finigan, K. Foote, A. K. Uryga, M. R. Bennett, M. spivakov, H. Jorgensen

This study identifies SCA1+ vascular smooth muscle cells as first responders that drive clonal proliferation in vascular injury and atherosclerosis.

bioRxiv · Oct 19, 2020Cell Biology

Evolution of multifunctionality through a pleiotropic substitution in the innate immune protein S100A9

J. L. Harman, A. N. Loes, G. D. Warren, M. C. Heaphy, K. J. Lampi, M. J. Harms

The paper shows how a single mutation in S100A9 affects its proinflammatory activity and proteolytic resistance while leaving S100A8/S100A9 antimicrobial activity unchanged, enabling multifunctionality in mammals.

bioRxiv · Dec 5, 2019Biochemistry