Author

K. J. Roberts

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:cryo-EM· 1 Research Focus:drug response / drug discovery· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

W. Cho· 2 shared Y. Cheng· 2 shared Y. Zhang· 2 shared A. Li· 1 shared A. Manglik· 1 shared A. Ralko· 1 shared A. Sharma· 1 shared B. R. Myers· 1 shared

Activity by Year

2018-2019 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersBiophysics

W. Cho

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2 papers

Recent·Most cited

Hedgehog pathway activation through conformational blockade of the Patched sterol conduit

Y. Zhang, W.-J. Lu, D. Bulkley, J. Liang, A. Ralko, K. J. Roberts, A. Li, W. Cho, Y. Cheng, A. Manglik, P. Beachy

This paper develops a nanobody agonist that activates the Hedgehog pathway by stabilizing an alternative conformation of Patched1, disrupting its sterol conduit and providing a new approach for transporter-related drug development.

bioRxiv · Sep 26, 2019Biophysics

Structural basis for cholesterol transport-like activity of the Hedgehog receptor Patched

Y. Zhang, D. P. Bulkley, K. J. Roberts, Y. Xin, D. Asarnow, A. Sharma, B. R. Myers, W. Cho, Y. Cheng, P. A. Beachy

This study presents a cryo-EM structure of Patched, revealing its structural similarity to RND transporters and suggesting a role in cholesterol transport.

bioRxiv · Jun 20, 2018Biophysics