Author

B. R. Myers

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Biophysics· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell signaling & trafficking· 3 Assay:cryo-EM· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

C. D. Arveseth· 3 shared I. B. Nelson· 3 shared J.-F. Zhu· 3 shared D. S. Hedeen· 2 shared J. L. Capener· 2 shared J. T. Happ· 2 shared M. F. Walker· 2 shared A. B. Long· 1 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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3 shared papersBiochemistry

C. D. Arveseth

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Author profile →

4 papers

Recent·Most cited

GRK2 Kinases in the Primary Cilium Initiate SMOOTHENED-PKA Signaling in the Hedgehog Cascade

M. F. Walker, J. Zhang, W. Steiner, P.-I. Ku, J.-F. Zhu, Z. Michaelson, Y.-C. Yen, A. Lee, A. B. Long, M. J. Casey, A. Poddar, I. B. Nelson, C. D. Arveseth, F. Nagel, R. Clough, , B. R. Myers

This study identifies GRK2-mediated phosphorylation of SMO in the primary cilium as a critical step initiating SMO-PKA signaling in the Hedgehog pathway.

bioRxiv · May 10, 2023Cell Biology

A PKA Inhibitor Motif within Smoothened Controls Hedgehog Signal Transduction

J. T. Happ, C. D. Arveseth, J. Bruystens, D. Bertinetti, I. B. Nelson, C. Olivieri, D. S. Hedeen, J.-F. Zhu, J. L. Capener, J. W. Bröckel, L. Vu, C. C. King, V. L. Ruiz-Perez, G. Veglia, F. W. Herberg, , B. R. Myers

This study identifies a PKA inhibitor motif in Smoothened that blocks PKA activity, enabling GLI activation in the Hedgehog pathway, revealing a mechanism similar to the Wnt cascade.

bioRxiv · Jul 5, 2021Biochemistry

Smoothened Transduces Hedgehog Signals via Activity-Dependent Sequestration of PKA Catalytic Subunits

C. D. Arveseth, J. T. Happ, D. S. Hedeen, J.-F. Zhu, J. L. Capener, D. K. Shaw, I. Deshpande, J. Liang, J. Xu, S. L. Stubben, I. B. Nelson, M. F. Walker, N. J. Krogan, D. J. Grunwald, R. Hüttenhain, , B. R. Myers

This study reveals that Smoothened (SMO) activates GLI transcription factors by sequestering PKA catalytic subunits at the membrane, bypassing traditional GPCR signaling mechanisms.

bioRxiv · Jul 1, 2020Biochemistry

Structural basis for cholesterol transport-like activity of the Hedgehog receptor Patched

Y. Zhang, D. P. Bulkley, K. J. Roberts, Y. Xin, D. Asarnow, A. Sharma, B. R. Myers, W. Cho, Y. Cheng, P. A. Beachy

This study presents a cryo-EM structure of Patched, revealing its structural similarity to RND transporters and suggesting a role in cholesterol transport.

bioRxiv · Jun 20, 2018Biophysics