Author

W.-J. Lu

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Bioengineering· 1 Biophysics· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:imaging· 1

Frequent Co-Authors

A. Li· 1 shared A. Manglik· 1 shared A. Ralko· 1 shared D. Bulkley· 1 shared D.-H. Wu· 1 shared F. Yang· 1 shared H.-B. Zhu· 1 shared J. Huang· 1 shared

Activity by Year

2019-2020 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

1 shared paperBiophysics

A. Li

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

A transferrable and interpretable multiple instance learning model for microsatellite instability prediction based on histopathology images

Z.-Y. Dong, R. Cao, F. Yang, S.-C. Ma, L. Liu, D.-H. Wu, Y. Li, Y. Zhao, T. Wang, W.-J. Lu, W.-J. Cai, H.-B. Zhu, X.-J. Guo, Y.-W. Lu, J.-J. Kuang, , J. Yao

This paper develops a transferable and interpretable deep learning model for MSI prediction from histopathology images, achieving high AUC scores in two cohorts.

bioRxiv · Feb 29, 2020 · PreprintBioengineering

Hedgehog pathway activation through conformational blockade of the Patched sterol conduit

Y. Zhang, W.-J. Lu, D. Bulkley, J. Liang, A. Ralko, K. J. Roberts, A. Li, W. Cho, Y. Cheng, A. Manglik, P. Beachy

This paper develops a nanobody agonist that activates the Hedgehog pathway by stabilizing an alternative conformation of Patched1, disrupting its sterol conduit and providing a new approach for transporter-related drug development.

bioRxiv · Sep 26, 2019Biophysics