Adenovirus transduction to express human ACE2 causes obesity-specific morbidity in mice, impeding studies on the effect of host nutritional status on SARS-CoV-2 pathogenesis.
P. Rai, C. Chuong, T. LeRoith, J. W. Smyth, N. K. Duggal, J. Weger-Lucarelli, J. Panov, M. Levi, K. K. Hall
This study shows that adenovirus-mediated ACE2 expression in mice causes obesity-specific morbidity, complicating research on SARS-CoV-2 pathogenesis in different nutritional states.
bioRxiv · May 26, 2021Pathology