P. Rai

ACSL4 activity drives TNBC metastasis by positively regulating Histone H3 Acetylation mediated SNAIL expression

This study identifies ACSL4 as a driver of TNBC metastasis by enhancing histone acetylation and SNAIL expression through metabolic and epigenetic mechanisms.

The soluble guanylyl cyclase pathway is inhibited to evade androgen deprivation-induced senescence and enable progression to castration resistance

This study identifies the soluble guanylyl cyclase (sGC) pathway as a target for castration-resistant prostate cancer (CRPC) treatment, showing that riociguat inhibits CRPC growth and enhances radiation response.

Widespread exposure to SARS-CoV-2 in wildlife communities

The paper documents SARS-CoV-2 exposure in six wildlife species and finds higher seroprevalence in areas with high human activity, suggesting human-to-animal transmission events.

The E2 glycoprotein holds key residues for Mayaro virus adaptation to the urban Aedes aegypti mosquito

This paper identifies a mutation in the E2 glycoprotein of Mayaro virus that enhances transmission in Aedes aegypti but reduces replication in human cells, suggesting a trade-off in host adaptation.

Gene expression based inference of drug resistance in cancer

This study uses gene expression data and machine learning to predict drug resistance in cancer by analyzing pathway activity patterns rather than gene expression levels alone.

Adenovirus transduction to express human ACE2 causes obesity-specific morbidity in mice, impeding studies on the effect of host nutritional status on SARS-CoV-2 pathogenesis.

This study shows that adenovirus-mediated ACE2 expression in mice causes obesity-specific morbidity, complicating research on SARS-CoV-2 pathogenesis in different nutritional states.

Mutational analysis unveils the temporal and spatial distribution of G614 genotype of SARS-CoV-2 in different Indian states and its association with case fatality rate of COVID-19

The paper analyzes the temporal and spatial distribution of the G614 genotype of SARS-CoV-2 in Indian states and finds a strong positive correlation with case fatality rate.