A limited number of double-strand DNA breaks are sufficient to delay cell cycle progression.
J. van den Berg, A. G. Manjon, K. Kielbassa, F. M. Feringa, R. Freire, R. H. Medema
The paper shows that a single DNA double-strand break can trigger a checkpoint response that delays cell cycle progression, and its abrogation leads to micronucleated daughter cells.
bioRxiv · May 7, 2018Cell Biology