R. Freire

A TOPBP1 Allele Causing Male Infertility Uncouples XY Silencing Dynamics From Sex Body Formation

This study identifies a TOPBP1 mutation causing male infertility by disrupting ATR-dependent MSCI dynamics without affecting SB formation.

Preclinical establishment of a divalent vaccine against SARS-CoV-2

This paper develops a divalent vaccine against SARS-CoV-2 that induces strong IgG responses and T-cell activation, showing durability and cross-variant protection.

Helminth infection modulates number and function of adipose tissue Tregs in high fat diet-induced obesity

This study shows that Heligmosomoides polygyrus infection reduces weight gain and metabolic dysfunctions in high fat diet-fed mice by modulating adipose tissue Treg cells.

ATR Inhibitors as Potent Modulators of DNA End Resection Capacity

This study shows that long-term ATR inhibition reduces DNA end resection and DNA repair efficiency in cancer cells, offering a strategy to enhance PARP inhibitor sensitivity.

Characterization of Pch2 localization determinants reveals a nucleolar- independent role in the meiotic recombination checkpoint

This study identifies Pch2 localization determinants and shows that its nucleolar localization is not required for the meiotic recombination checkpoint.

A limited number of double-strand DNA breaks are sufficient to delay cell cycle progression.

The paper shows that a single DNA double-strand break can trigger a checkpoint response that delays cell cycle progression, and its abrogation leads to micronucleated daughter cells.