Author

J. van den Berg

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Cell Biology· 3 Cancer Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:drug response / drug discovery· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

A. G. Manjon· 2 shared F. M. Feringa· 2 shared R. H. Medema· 2 shared A. Biran· 1 shared A. F. M. Dost· 1 shared A. Groth· 1 shared A. J. Morris· 1 shared A. Mazzocca· 1 shared

Activity by Year

2018-2024 · peak 1/yr

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10 top collaborators · 10 mutual co-author links

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2 shared papersCell Biology

A. G. Manjon

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Author profile →

5 papers

Recent·Most cited

Acute multi-level response to defective de novo chromatin assembly in S-phase

J. Dreyer, G. Ricci, J. van den Berg, V. Bhardwaj, J. Funk, C. Armstrong, V. van Batenburg, C. Sine, M. A. Vaninsberghe, R. Marsman, I. K. Mandemaker, S. di Sanzo, J. Costantini, S. Manzo, A. Biran, , F. Mattiroli

This study investigates the acute effects of CAF-1 loss on chromatin assembly during S-phase, revealing multi-level responses including replication slowdown and histone modification changes.

bioRxiv · Mar 22, 2024Cell Biology

Druggable Growth Dependencies and Tumor Evolution Analysis in Patient-Derived Organoids of Neuroendocrine Cancer

T. L. Dayton, N. Alcala, L. Moonen, L. den Hartigh, L. Mangiante, L. Lap, A. F. M. Dost, J. Beumer, S. Levy, R. S. van Leeuwaarde, W. M. Hackeng, K. Samsom, C. Voegele, A. Sexton-Oates, H. Begthel, , H. Clevers

This study establishes patient-derived tumor organoids (PDTOs) for neuroendocrine cancers, identifies therapeutic vulnerabilities, and highlights EGF dependency in pulmonary neuroendocrine tumors.

bioRxiv · Oct 31, 2022Cancer Biology

DNA end-resection in highly accessible chromatin produces a toxic break

J. van den Berg, S. E. P. Joosten, Y. Kim, A. G. Manjon, L. Krenning, L. Koob, F. M. Feringa, R. Klompmaker, B. van den Broek, K. Jalink, W. Zwart, R. H. Medema

The authors withdrew their manuscript due to inconsistencies in data and questionable experimental results regarding DNA end-resection and chromatin accessibility.

bioRxiv · Aug 30, 2021 · PreprintCell Biology

Autotaxin impedes anti-tumor immunity by suppressing chemotaxis and tumor infiltration of CD8+ T cells

E. Matas-Rico, E. Frijlink, I. van der Haar Avila, A. Menegakis, M. van Zon, A. J. Morris, J. Koster, F. Salgado-Polo, S. de Kivit, T. Lanca, A. Mazzocca, Z. Johnson, J. Haanen, T. N. Schumacher, A. Perrakis, , W. H. Moolenaar

This study shows that ATX secreted by melanoma cells repels CD8+ T cells, reducing their infiltration into tumors and impairing anti-tumor immunity.

bioRxiv · Feb 26, 2020Cancer Biology

A limited number of double-strand DNA breaks are sufficient to delay cell cycle progression.

J. van den Berg, A. G. Manjon, K. Kielbassa, F. M. Feringa, R. Freire, R. H. Medema

The paper shows that a single DNA double-strand break can trigger a checkpoint response that delays cell cycle progression, and its abrogation leads to micronucleated daughter cells.

bioRxiv · May 7, 2018Cell Biology