Extracellular Matrix Dysfunction in Sorsby Patient-Derived Retinal Pigment Epithelium
A. L. Engel, Y. Wang, T. Khuu, E. Worrall, M. A. Manson, R. R. Lim, K. Knight, A. Yanagida, J. H. Qi, A. Ramakrishnan, R. G. Weleber, M. Klein, D. J. Wilson, B. Anand-Apte, J. B. Hurley, , J. R. Chao
This study examines SFD patient-derived iPSC-RPE for extracellular matrix dysfunction and oxidative stress, finding increased sub-RPE deposits and elevated 4-hydroxyproline levels.
bioRxiv · Jan 6, 2021Cell Biology