J. B. Hurley

Acetyl-CoA carboxylase inhibition increases RPE cell fatty acid oxidation and limits apolipoprotein efflux

This study shows that inhibiting acetyl-CoA carboxylase with Firsocostat increases fatty acid oxidation and reduces lipid deposits in RPE cells, potentially limiting drusen accumulation in AMD.

Proline provides a nitrogen source in the retinal pigment epithelium to synthesize and export amino acids for the neural retina

This study shows the retinal pigment epithelium uses proline nitrogen to produce and export amino acids to the neural retina, highlighting its role in retinal metabolism.

In vivo exchange of glucose and lactate between photoreceptors and the retinal pigment epithelium

The paper demonstrates that photoreceptors supply lactate to the RPE, supporting a metabolic exchange between these retinal cells.

Medium depth influences O2 availability and metabolism in cultured RPE cells

This study shows that medium volume in RPE cell cultures affects O2 availability, altering metabolism and lipid droplet dynamics, and suggests optimal conditions for studying oxidative metabolism in RPE cells.

Monocarboxylate Transporter 1 (MCT1) mediates succinate export in the retina

The paper identifies MCT1 as the transporter mediating succinate export from retinas but finds no MCT-mediated import into RPE.

Metabolic function in aging retina and retinal pigment epithelium remains robust despite vision loss

This study examines metabolic changes in aging mouse retina and eyecup, finding stable glucose and glutamine metabolism despite vision loss.

Fluidics System for Resolving Concentration-Dependent Effects of Dissolved Gases on Tissue Metabolism

This paper introduces a fluidics system to study how dissolved gases affect tissue metabolism and function, revealing new insights into oxygen consumption and hydrogen sulfide effects on insulin secretion.

Succinate metabolism uncouples retinal pigment epithelium mitochondria

The paper investigates succinate metabolism in retinal pigment epithelium and finds that succinate consumption by eyecup tissue uncouples mitochondrial ATP synthesis from respiration.

Extracellular Matrix Dysfunction in Sorsby Patient-Derived Retinal Pigment Epithelium

This study examines SFD patient-derived iPSC-RPE for extracellular matrix dysfunction and oxidative stress, finding increased sub-RPE deposits and elevated 4-hydroxyproline levels.

Non-photopic and photopic visual cycles differentially regulate immediate, early and late-phases of cone photoreceptor-mediated vision

This study investigates how non-photopic and photopic visual cycles regulate different phases of cone photoreceptor-mediated vision in zebrafish, revealing distinct roles of Rpe65 and Des1 in bright light vision.

Succinate can shuttle reducing power from the hypoxic retina to the O2-rich pigment epithelium.

The paper shows that succinate shuttles reducing power from the hypoxic retina to the O2-rich pigment epithelium via a malate/succinate cycle.

Mitochondrial Ca2+ influences photoresponse recovery, metabolism, and mitochondrial localization in cone photoreceptors

This study shows that low mitochondrial Ca2+ uptake in zebrafish cone photoreceptors affects photoresponse recovery, metabolism, and mitochondrial localization, with increased MCU expression altering these processes.

Biochemical Adaptations Of The Retina And Retinal Pigment Epithelium Support A Metabolic Ecosystem In The Vertebrate Eye

The paper presents a model of retinal metabolism showing glucose is converted to lactate by photoreceptors and used by retinal pigment epithelium and Muller glial cells, with implications for retinal disease and therapy.