Author

J. R. Chao

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 5 Cell Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 6 Approach:experimental assay· 5 Assay:metabolomics· 5 Research Focus:metabolism & bioenergetics· 4 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Organism:mouse· 2 Assay:proteomics· 2

Frequent Co-Authors

A. L. Engel· 4 shared J. B. Hurley· 4 shared J. Du· 4 shared Y. Wang· 3 shared B. Li· 2 shared M. Sadilek· 2 shared R. R. Lim· 2 shared A. Engel· 1 shared

Activity by Year

2017-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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4 shared papersBiochemistry

A. L. Engel

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Author profile →

6 papers

Recent·Most cited

Metabolic phenotyping of healthy and diseased human RPE cells

S. Rizwan, B. Toothman, B. Li, A. J. Engel, R. R. Lim, S. Niernberger, J. Lu, C. Ratcliff, Y. Xiang, M. Eminhizer, J. R. Chao, J. Du

This study identifies nutrient utilization differences between healthy and diseased human RPE cells, showing reduced metabolic flexibility in SFD RPE and the impact of differentiation on nutrient use.

bioRxiv · Feb 28, 2024Biochemistry

Acetyl-CoA carboxylase inhibition increases RPE cell fatty acid oxidation and limits apolipoprotein efflux

D. T. Hass, K. Pandey, A. L. Engel, N. Horton, B. M. Robbings, R. Lim, M. Sadilek, Q. Zhang, G. A. Autterson, J. M. Miller, J. R. Chao, J. B. Hurley

This study shows that inhibiting acetyl-CoA carboxylase with Firsocostat increases fatty acid oxidation and reduces lipid deposits in RPE cells, potentially limiting drusen accumulation in AMD.

bioRxiv · Nov 7, 2023 · PreprintBiochemistry

Proline provides a nitrogen source in the retinal pigment epithelium to synthesize and export amino acids for the neural retina

S. Zhu, R. Xu, A. Engel, Y. Wang, R. McNeel, J. B. Hurley, J. R. Chao, J. Du

This study shows the retinal pigment epithelium uses proline nitrogen to produce and export amino acids to the neural retina, highlighting its role in retinal metabolism.

bioRxiv · Apr 18, 2023Biochemistry

Extracellular Matrix Dysfunction in Sorsby Patient-Derived Retinal Pigment Epithelium

A. L. Engel, Y. Wang, T. Khuu, E. Worrall, M. A. Manson, R. R. Lim, K. Knight, A. Yanagida, J. H. Qi, A. Ramakrishnan, R. G. Weleber, M. Klein, D. J. Wilson, B. Anand-Apte, J. B. Hurley, , J. R. Chao

This study examines SFD patient-derived iPSC-RPE for extracellular matrix dysfunction and oxidative stress, finding increased sub-RPE deposits and elevated 4-hydroxyproline levels.

bioRxiv · Jan 6, 2021Cell Biology

Inhibition of mitochondrial respiration impairs nutrient consumption and metabolite transport in human retinal pigment epithelium

R. Zhang, A. L. Engel, Y. Wang, B. Li, W. Shen, M. C. Gillies, J. R. Chao, J. Du

This study shows that inhibiting mitochondrial respiration in RPE cells alters intracellular and extracellular metabolites, revealing a metabolic signature of mitochondrial dysfunction.

bioRxiv · May 11, 2020Biochemistry

Biochemical Adaptations Of The Retina And Retinal Pigment Epithelium Support A Metabolic Ecosystem In The Vertebrate Eye

M. A. Kanow, M. M. Giarmarco, C. Jankowski, K. Tsantilas, A. L. Engel, J. Du, J. D. Linton, C. C. Farnsworth, S. R. Sloat, K. J. Lindsay, E. D. Parker, S. E. Brockerhoff, M. Sadilek, J. R. Chao, J. B. Hurley

The paper presents a model of retinal metabolism showing glucose is converted to lactate by photoreceptors and used by retinal pigment epithelium and Muller glial cells, with implications for retinal disease and therapy.

bioRxiv · May 29, 2017Biochemistry