Author

D. J. Wilson

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 4 Evolutionary Biology· 2 Bioengineering· 1 Cell Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:human· 4 Research Focus:drug response / drug discovery· 2 Assay:proteomics· 2 Approach:statistical model· 2 Assay:whole-genome sequencing· 2 Organism:bacteria (other)· 1 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

E. Z. WOLF· 2 shared A. J. Lamberto· 1 shared A. L. Engel· 1 shared A. M. Barsotti· 1 shared A. Pon· 1 shared A. Ramakrishnan· 1 shared a. spicakova· 1 shared A. Tandon· 1 shared

Activity by Year

2017-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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2 shared papersBiochemistry

E. Z. WOLF

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

Recruitment of FBXO22 for Targeted Degradation of NSD2

D. Y. Nie, J. R. Tabor, J. Li, M. Kutera, J. St-Germain, R. P. Hanley, E. Z. WOLF, E. Paulakonis, T. M. G. Kenney, S. Duan, S. Shrestha, D. D. Owens, A. Pon, M. Szewczyk, A. J. Lamberto, , C. Arrowsmith

This paper describes a targeted protein degradation strategy using UNC8732 to recruit FBXO22 for NSD2 degradation, leading to growth suppression and reversal of drug resistance in leukemia cells.

bioRxiv · Nov 1, 2023Biochemistry

In Vitro Safety Signals for Potential Clinical Development of the Anti-Inflammatory Pregnane X Receptor Agonist FKK6

Z. Dvorak, B. Vyhlidalov, P. Pecinkov, H. Li, P. Anzenbacher, a. spicakova, e. anzenbacherova, V. Chow, J. LIU, H. Krause, D. J. Wilson, T. Beres, P. Tarkowski, D. Chen, S. Mani

This paper performs in vitro pharmacological profiling of FKK6, showing high PXR selectivity, intestinal permeability, and rapid metabolism, supporting its potential preclinical development.

bioRxiv · Oct 21, 2023Biochemistry

Microbially Driven Reversible Actuation and Color Changing Materials

H. Y. Kuang, S. Bonanno, W.-T. Chang, D. Q. Bower, V. M. Pratt, J. Zerkowski, N. Scaperdas, L. A. Young, D. J. Wilson, L. F. Deravi, N. S. Joshi

This paper demonstrates an engineered living material driven by E. coli that reversibly swells and de-swells a pH-responsive hydrogel, accompanied by a color change.

bioRxiv · Sep 29, 2023 · PreprintBioengineering

Small molecule screen identifies non-catalytic USP3 chemical handle

M. K. Mann, E. Z. WOLF, M. Silva, B. Wilson, D. J. Wilson, R. J. Harding, M. Schapira

The paper identifies a small molecule ligand for the ZnF-UBD of USP3 with a KD of 14 µM, which could serve as a starting point for developing DUBTACs.

bioRxiv · Mar 1, 2023Biochemistry

Evolutionary processes driving the rise and fall of Staphylococcus aureus ST239, a dominant hybrid pathogen

J. L. Gill, J. Hedge, D. J. Wilson, C. MacLean

This study investigates the evolutionary history of Staphylococcus aureus ST239, finding it originated before methicillin use and has low fitness, contributing to its decline.

bioRxiv · Jan 10, 2021Evolutionary Biology

Extracellular Matrix Dysfunction in Sorsby Patient-Derived Retinal Pigment Epithelium

A. L. Engel, Y. Wang, T. Khuu, E. Worrall, M. A. Manson, R. R. Lim, K. Knight, A. Yanagida, J. H. Qi, A. Ramakrishnan, R. G. Weleber, M. Klein, D. J. Wilson, B. Anand-Apte, J. B. Hurley, , J. R. Chao

This study examines SFD patient-derived iPSC-RPE for extracellular matrix dysfunction and oxidative stress, finding increased sub-RPE deposits and elevated 4-hydroxyproline levels.

bioRxiv · Jan 6, 2021Cell Biology

Conformational dynamics of -synuclein during the interaction with phospholipid nanodiscs by Millisecond Hydrogen Deuterium Exchange Mass Spectrometry

I. Oganesyan, C. Lento, A. Tandon, D. J. Wilson

This study uses HDX-MS to analyze conformational changes in α-synuclein when interacting with different lipid nanodiscs, identifying regions critical for amyloidogenic aggregation.

bioRxiv · Nov 16, 2020Biochemistry

Panton-Valentine leukocidin is the key determinant of Staphylococcus aureus pyomyositis in a bacterial genome-wide association study

B. C. Young, S. G. Earle, S. Soeng, P. Sar, V. Kumar, S. Hor, V. Sar, R. Bousfield, N. D. Sanderson, L. Barker, N. Stoesser, K. R. Emary, C. M. Parry, E. K. Nickerson, P. Turner, , C. E. Moore

bioRxiv · Sep 29, 2018 · PreprintMicrobiology

The Bacterial Sequential Markov Coalescent

N. De Maio, D. J. Wilson

This paper introduces a new model, BSMC, to approximate bacterial recombination and presents a simulation tool, FastSimBac, for efficient genomic evolution studies.

Genetics · May 1, 2017Peer-reviewedEvolutionary Biology