K. Kooiker

Identifying mechanisms and therapeutic targets in muscle using Bayesian parameter estimation with conditional variational autoencoders

This paper uses a Conditional Variational Autoencoder to predict muscle twitch parameters from simulated and experimental data, identifying therapeutic targets for a cardiac mutation.

Late-life Rapamycin Treatment Enhances Cardiomyocyte Relaxation Kinetics and Reduces Myocardial Stiffness

This study shows that late-life rapamycin treatment improves cardiomyocyte relaxation and reduces myocardial stiffness in aged mice, reversing diastolic dysfunction.