Author

Y. A. Chiao

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 5

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:mouse· 5 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Assay:metabolomics· 2 Assay:proteomics· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

P. S. Rabinovitch· 3 shared C. F. Lee· 2 shared D. Marcinek· 2 shared H. Granzier· 2 shared A. Batushansky· 1 shared A. Chakraborty· 1 shared A. D. Chakraborty· 1 shared A. Pranay· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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3 shared papersPhysiology

P. S. Rabinovitch

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5 papers

Recent·Most cited

Loss of cardiac PFKFB2 drives Metabolic, Functional, and Electrophysiological Remodeling in the Heart

K. M. Harold, S. Matsuzaki, A. Pranay, B. L. Loveland, A. Batushansky, M. F. Mendez Garcia, C. A. Eyster, S. Stavrakis, Y. A. Chiao, M. Kinter, K. M. Humphries

This study shows that loss of cardiac PFKFB2 leads to metabolic, functional, and electrophysiological changes in the heart, including impaired systolic function and altered electrophysiology.

bioRxiv · Nov 22, 2023Physiology

Late-life Rapamycin Treatment Enhances Cardiomyocyte Relaxation Kinetics and Reduces Myocardial Stiffness

A. D. Chakraborty, K. Kooiker, K. A. Kobak, Y. Cheng, C. F. Lee, M. Razumova, H. Granzier, M. Regnier, P. S. Rabinovitch, F. Moussavi-Harami, Y. A. Chiao

This study shows that late-life rapamycin treatment improves cardiomyocyte relaxation and reduces myocardial stiffness in aged mice, reversing diastolic dysfunction.

bioRxiv · Jun 12, 2023 · PreprintPhysiology

Intermittent treatment with elamipretide preserves exercise tolerance in aged female mice

M. D. Campbell, A. T. Samuelson, Y. A. Chiao, M. T. Sweetwyne, W. C. Ladiges, P. S. Rabinovitch, D. Marcinek

This study shows that intermittent elamipretide injections in aged mice preserve exercise tolerance and skeletal muscle function but not heart or kidney function, unlike continuous treatment.

bioRxiv · Nov 29, 2022Physiology

NAD+ Redox Imbalance in the Heart Exacerbates Diabetic Cardiomyopathy

Y. A. Chiao, A. Chakraborty, C. Light, R. Tian, J. Sadoshima, X. Shi, H. Gu, C. F. Lee

This study shows that NAD+ redox imbalance worsens diabetic cardiomyopathy by impairing cardiomyocyte function and suggests NAMPT as a therapeutic target.

bioRxiv · Jul 3, 2020Physiology

Late-life restoration of mitochondrial function reverses cardiac dysfunction in old mice

Y. A. Chiao, H. Zhang, M. Sweetwyne, J. Whitson, Y. S. Ting, N. Basisty, L. Pino, E. Quarles, N.-H. Nguyen, M. Campbell, T. Zhang, M. J. Gaffrey, G. Merrihew, L. Wang, Y. Yue, , P. S. Rabinovitch

This study shows that treating old mice with SS-31 improves cardiac diastolic function by reducing mitochondrial oxidative stress and restoring redox balance.

bioRxiv · Jan 2, 2020Physiology