Late-life Rapamycin Treatment Enhances Cardiomyocyte Relaxation Kinetics and Reduces Myocardial Stiffness
A. D. Chakraborty, K. Kooiker, K. A. Kobak, Y. Cheng, C. F. Lee, M. Razumova, H. Granzier, M. Regnier, P. S. Rabinovitch, F. Moussavi-Harami, Y. A. Chiao
This study shows that late-life rapamycin treatment improves cardiomyocyte relaxation and reduces myocardial stiffness in aged mice, reversing diastolic dysfunction.
bioRxiv · Jun 12, 2023 · PreprintPhysiology