P. S. Rabinovitch

This study shows that late-life rapamycin treatment improves cardiomyocyte relaxation and reduces myocardial stiffness in aged mice, reversing diastolic dysfunction.

This study shows that intermittent elamipretide injections in aged mice preserve exercise tolerance and skeletal muscle function but not heart or kidney function, unlike continuous treatment.

This study investigates how elamipretide affects age-related post-translational modifications in mouse heart proteins, finding that it reverses oxidative changes but not phosphorylation changes.

This study examines metabolic changes in aging mouse retina and eyecup, finding stable glucose and glutamine metabolism despite vision loss.

This study identifies increased proton leak in aged cardiomyocytes as a mechanism of cardiac dysfunction and shows that SS-31 reverses this by targeting ANT1 and mitochondrial function.

This study shows that treating old mice with SS-31 improves cardiac diastolic function by reducing mitochondrial oxidative stress and restoring redox balance.