Boosting the Sensitivity of Quantitative Single-Cell Proteomics with Activated Ion-Tandem Mass Tags (AI-TMT)
T. Peters-Clarke, Y. Liang, K. L. Mertz, K. W. Lee, M. S. Westphall, J. D. Hinkle, G. C. McAlister, J. E. P. Syka, R. T. Kelly, J. Coon
This paper introduces AI-TMT, a method enhancing single-cell proteomics sensitivity by improving reporter ion generation, resulting in higher signal and faster analysis.
bioRxiv · Feb 24, 2024 · PreprintBiochemistry