Author

K. M. Alp

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:proteomics· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2

Frequent Co-Authors

R. Sakson· 2 shared T. Ruppert· 2 shared A. R. Ormsby· 1 shared A.-C. Gingras· 1 shared B. Larsen· 1 shared B. Niesler· 1 shared C. Bakal· 1 shared C. Barth· 1 shared

Activity by Year

2018-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersCell Biology

R. Sakson

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3 papers

Recent·Most cited

Replicative aging impedes stress-induced assembly of a key human protein disaggregase

Y. Mathangasinghe, N. Alberts, C. J. Rosado, D. Cox, N. L. Payne, A. R. Ormsby, K. M. Alp, R. Sakson, S. Uthishtran, T. Ruppert, S. Arumugam, D. M. Hatters, H. H. Kampinga, N. B. Nillegoda

This study identifies a stress-induced trimeric protein disaggregase in human cells that collapses during replicative aging, contributing to pathophysiological consequences.

bioRxiv · Jun 25, 2022 · PreprintCell Biology

Targeted Proteomics Reveals Quantitative Differences in Low Abundance Glycosyltransferases of Patients with Congenital Disorders of Glycosylation

R. Sakson, L. Beedgen, P. Bernhard, K. M. Alp, N. Luebbehusen, R. Roeth, B. Niesler, M. P. Mayer, C. Thiel, T. Ruppert

This study develops a targeted proteomics assay to quantify low-abundance glycosyltransferases in CDG patients, revealing specific protein level changes in ALG1 and ALG2 mutants.

bioRxiv · Sep 15, 2020Biochemistry

Spatial Organization of Rho GTPase signaling by RhoGEF/RhoGAP proteins

P. M. Mueller, J. Rademacher, R. D. Bagshaw, K. M. Alp, G. Giudice, L. E. Heinrich, C. Barth, R. L. Eccles, M. Sanchez-Castro, L. Brandenburg, G. Mbamalu, M. Tucholska, L. Spatt, C. Wortmann, M. T. Czajkowski, , O. Rocks

The paper characterizes RhoGEF/RhoGAP substrate specificities, localization, and interactomes to reveal their role in spatially organizing Rho signaling.

bioRxiv · Aug 29, 2018Cell Biology