M. P. Mayer

Induction of mitochondrial heat shock proteins and mitochondrial biogenesis in endothelial cells upon acute methylglyoxal stress: Evidence for hormetic autofeedback

This study shows that knocking out HSPA1A/HSPA1B in mouse endothelial cells leads to increased mitochondrial biogenesis and chaperone expression under methylglyoxal stress.

Direct observation of Hsp90-induced compaction in a protein chain

This study uses optical tweezers to show Hsp90 induces local contractions in unfolded protein chains, leading to global compaction and suppression of misfolding and aggregation.

Co-chaperone involvement in knob biogenesis implicates host-derived chaperones in malaria virulence

This study shows that the malaria parasite protein PFA66, a J-domain protein, works with host-derived HSP70 to facilitate knob biogenesis and cytoadherence in infected erythrocytes.

Hsf1 is SUMOylated in the activated trimeric state

This study investigates how SUMOylation affects Hsf1 activity in vitro, finding that SUMOylation occurs in the activated trimeric state of Hsf1.

Targeted Proteomics Reveals Quantitative Differences in Low Abundance Glycosyltransferases of Patients with Congenital Disorders of Glycosylation

This study develops a targeted proteomics assay to quantify low-abundance glycosyltransferases in CDG patients, revealing specific protein level changes in ALG1 and ALG2 mutants.

Refolding activity of bacterial Hsp90 in vivo reveals ancient chaperoning function

This study shows that bacterial Hsp90 enhances protein refolding after heat stress but is not required for de novo folding, revealing its ancient role in the chaperone cascade.

Breaking the Deadlock of Molecular Chaperones

This paper proposes a mechanism where Hsp70 and Hsp90 chaperones facilitate protein folding by creating a hydrophobicity gradient, allowing productive folding to occur.